Two sample MR report
RPS26_Alveolar Macrophages against bbj-a-88
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 8 | 0.1712915 | 0.4141476 | 0.6935434 |
| Weighted median | 8 | 0.1612030 | 0.0183718 | 0.0000000 |
| Inverse variance weighted | 8 | 0.1101580 | 0.0450661 | 0.0145108 |
| Simple mode | 8 | 0.1732844 | 0.0203221 | 0.0000605 |
| Weighted mode | 8 | 0.1647454 | 0.0187054 | 0.0000491 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 118.6634 | 6 | 0 |
| Inverse variance weighted | 119.1003 | 7 | 0 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0393357 | 0.2646387 | 0.886708 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.000394 | 1e-06 | TRUE | 0.0724985 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
